The base of so many great cannabis products starts with great cannabis oil. At Caliva, we invest in innovation and utilize cutting-edge oil extraction and refinement technology to to produce high purity cannabis oil. Our team of cultivators, scientists, and artisan formulators work together to produce the perfect oil blend to fit your product development needs. From vape cartridges, to specialty topicals, edibles and tincture, our oil formulations serve as the basis for high quality cannabis products. All Caliva oils are tested to 2018 California state standards. Our oil is sold by the kilo only and shipped in laboratory grade glass. 
THC is the primary psychoactive compound in marijuana and it is what people are searching for when they want a product that gives them a "high." Unlike THC, CBD isn't known to cause psychoactive effects, and is therefore attractive to those who want to avoid the high but who believe there are other benefits of CBD, said Sara Ward, a pharmacologist at Temple University in Philadelphia. [Healing Herb? Marijuana Could Treat These 5 Conditions]
Tobacco is responsible for about one in five cancer deaths worldwide[36] and about one in three in the developed world.[37] Lung cancer death rates in the United States have mirrored smoking patterns, with increases in smoking followed by dramatic increases in lung cancer death rates and, more recently, decreases in smoking rates since the 1950s followed by decreases in lung cancer death rates in men since 1990.[38][39]
Radiation therapy is used in about half of cases. The radiation can be either from internal sources (brachytherapy) or external sources. The radiation is most commonly low energy x-rays for treating skin cancers, while higher energy x-rays are used for cancers within the body.[154] Radiation is typically used in addition to surgery and or chemotherapy. For certain types of cancer, such as early head and neck cancer, it may be used alone.[155] For painful bone metastasis, it has been found to be effective in about 70% of patients.[155]
CBD does not appear to have any psychotropic ("high") effects such as those caused by ∆9-THC in marijuana, but may have anti-anxiety and anti-psychotic effects.[10] As the legal landscape and understanding about the differences in medical cannabinoids unfolds, experts are working to distinguish "medical marijuana" (with varying degrees of psychotropic effects and deficits in executive function) – from "medical CBD therapies” which would commonly present as having a reduced or non-psychoactive side-effect profile.[10][59]
Kimberly is the reference editor for Live Science and Space.com. She has a bachelor's degree in marine biology from Texas A&M University, a master's degree in biology from Southeastern Louisiana University and a graduate certificate in science communication from the University of California, Santa Cruz. Her favorite stories include animals and obscurities. A Texas native, Kim now lives in a California redwood forest. You can follow her on Twitter @kimdhickok.
^ Nadulski T, Pragst F, Weinberg G, Roser P, Schnelle M, Fronk EM, Stadelmann AM (December 2005). "Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract". Ther Drug Monit. 27 (6): 799–810. doi:10.1097/01.ftd.0000177223.19294.5c. PMID 16306858.
In order to create a system where oils can be provided to patients when the original prescription is expressed in grams of dried product, each Licensed Producer must provide an ‘Equivalency Factor’. This allows you to see how much oil you can purchase to be in line with your prescription and ensures that you do not go over your prescribed allowance. For example, a 60ml bottle of Blueberry Lamsbread Cannabis Oil, which has an equivalency factor of 12 ml of oil to 1 gram of dried cannabis, will use 5 grams of your possession limit.
When exposed to air, warmth and light (especially without antioxidants), the oil loses its taste and psychoactivity due to aging. Cannabinoid carboxylic acids (THCA, CBDA, and maybe others) have an antibiotic effect on gram-positive bacteria such as (penicillin-resistant) Staphylococcus aureus, but gram-negative bacteria such as Escherichia coli are unaffected.[26]
Cancer - the Brave Crab Sent to this Earth by something they believe in, only to mess with someone bigger than they are, this isn't an animal aware of their strength. Patriotism can make them endanger their own wellbeing, fighting for someone else's cause, as if others can become their higher power. The Crab knows where they're going, but this is often in a wrong direction, at least until they learn their lessons and start relying solely on themselves.

31 January 2019 ¦ GENEVA: Ahead of World Cancer Day (4 February), the World Health Organization (WHO) has released new guidance on managing cancer pain, with a view to improving the health sector response and ending the needless suffering of cancer patients. Around the world, pain is experienced by more than half (55%) of patients undergoing treatment for cancer and two thirds (66%) of people with advanced or terminal cancer. The WHO Guidelines for the pharmacologic and radiotherapeutic management of cancer pain in adults and adolescents provide evidence-based guidance to health-care providers on appropriate approaches to the medical and radiotherapeutic management of cancer pain. This includes guidance on the choice of analgesic medicines (painkillers); the use of adjuvant medicines (steroids), and specific techniques for treating pain from bone metastases (bisphosphonates and radiotherapy).


CBD Isolates/Concentrates: Anyone familiar with smoking hash or other cannabis concentrates like wax and BHO will be no stranger to this delivery method. Simply sprinkle some into a vaporizer or water pipe, ignite, inhale, and enjoy! We find that this option is useful for individuals looking to elevate their regular consumption of CBD-rich cannabis flowers or other smokable herbs.
Individuals with arthritis can benefit from both physical and occupational therapy. In arthritis the joints become stiff and the range of movement can be limited. Physical therapy has been shown to significantly improve function, decrease pain, and delay need for surgical intervention in advanced cases.[43] Exercise prescribed by a physical therapist has been shown to be more effective than medications in treating osteoarthritis of the knee. Exercise often focuses on improving muscle strength, endurance and flexibility. In some cases, exercises may be designed to train balance. Occupational therapy can provide assistance with activities. Assistive technology is a tool used to aid a person's disability by reducing their physical barriers by improving the use of their damaged body part, typically after an amputation. Assistive technology devices can be customized to the patient or bought commercially.[44]

Uric acid is formed as the body breaks down purines, a substance found in human cells and in many foods. Some people have high levels of uric acid because they naturally produce more than is needed or the body can’t get rid of the uric acid quickly enough. In some people the uric acid builds up and forms needle-like crystals in the joint, resulting in sudden spikes of extreme joint pain, or a gout attack. Gout can come and go in episodes or, if uric acid levels aren’t reduced, it can become chronic, causing ongoing pain and disability.
In fact, the U.S. Food and Drug Administration (FDA) approved Epidiolex (a drug made with a purified form of CBD oil) in June 2018 for the treatment of seizures associated with two rare and severe forms of epilepsy in patients 2 years of age and older. These two epilepsy forms are known as Lennox-Gastaut syndrome and Dravet syndrome. Epidiolex is the first FDA-approved drug that contains a purified drug substance derived from marijuana.
Diabetes can occur temporarily during pregnancy, and reports suggest that it occurs in 2% to 10% of all pregnancies. Significant hormonal changes during pregnancy can lead to blood sugar elevation in genetically predisposed individuals. Blood sugar elevation during pregnancy is called gestational diabetes. Gestational diabetes usually resolves once the baby is born. However, 35% to 60% of women with gestational diabetes will eventually develop type 2 diabetes over the next 10 to 20 years, especially in those who require insulin during pregnancy and those who remain overweight after their delivery. Women with gestational diabetes are usually asked to undergo an oral glucose tolerance test about six weeks after giving birth to determine if their diabetes has persisted beyond the pregnancy, or if any evidence (such as impaired glucose tolerance) is present that may be a clue to a risk for developing diabetes.

There are different types of brain and spinal cord tumors. These tumors are named based on the type of cell in which they formed and where the tumor first formed in the central nervous system. For example, an astrocytic tumor begins in star-shaped brain cells called astrocytes, which help keep nerve cells healthy. Brain tumors can be benign (not cancer) or malignant (cancer).
In general, the majority of people end up using higher-strength products for pain than they would for things like anxiety, stress, or depression. The majority of today’s best CBD oil manufacturers offer tinctures in three different “potencies,” usually in 100, 300, or 600 mg options. Many people start on a middle ground with a 300 mg option, and work your way up from there, but it is extremely important to consult with the brand you are purchasing from before consumption.

Treatment is generally the same as for non-pregnant women. However, radiation and radioactive drugs are normally avoided during pregnancy, especially if the fetal dose might exceed 100 cGy. In some cases, some or all treatments are postponed until after birth if the cancer is diagnosed late in the pregnancy. Early deliveries are often used to advance the start of treatment. Surgery is generally safe, but pelvic surgeries during the first trimester may cause miscarriage. Some treatments, especially certain chemotherapy drugs given during the first trimester, increase the risk of birth defects and pregnancy loss (spontaneous abortions and stillbirths).[219]


There are two major types of diabetes, called type 1 and type 2. Type 1 diabetes was also formerly called insulin dependent diabetes mellitus (IDDM), or juvenile-onset diabetes mellitus. In type 1 diabetes, the pancreas undergoes an autoimmune attack by the body itself, and is rendered incapable of making insulin. Abnormal antibodies have been found in the majority of patients with type 1 diabetes. Antibodies are proteins in the blood that are part of the body's immune system. The patient with type 1 diabetes must rely on insulin medication for survival.
for colon cancer, see Engstrom PF, Arnoletti JP, Benson AB, Chen YJ, Choti MA, Cooper HS, Covey A, Dilawari RA, Early DS, Enzinger PC, Fakih MG, Fleshman J, Fuchs C, Grem JL, Kiel K, Knol JA, Leong LA, Lin E, Mulcahy MF, Rao S, Ryan DP, Saltz L, Shibata D, Skibber JM, Sofocleous C, Thomas J, Venook AP, Willett C (September 2009). "NCCN Clinical Practice Guidelines in Oncology: colon cancer". Journal of the National Comprehensive Cancer Network. 7 (8): 778–831. PMID 19755046.
People with diabetes can benefit from education about the disease and treatment, good nutrition to achieve a normal body weight, and exercise, with the goal of keeping both short-term and long-term blood glucose levels within acceptable bounds. In addition, given the associated higher risks of cardiovascular disease, lifestyle modifications are recommended to control blood pressure.[80][81]

But even though it's infiltrating pretty much every corner of the wellness world (hi, vegan CBD brownies!) many people still find CBD a little confusing—especially when it comes to figuring out the right way to use it and how to make sure the stuff you're buying is, you know, actually legit. Below, we asked experts to answer the most pressing questions about CBD.


CBD shows promise in the treatment of anxiety disorders, according to a report published in the journal Neurotherapeutics in 2015. Looking at results from experimental research, clinical trials, and epidemiological studies, the report’s authors found evidence that CBD may help treat generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. However, the authors caution that human-based research on CBD and anxiety is fairly limited at this point.
The causes of arthritis depend on the form of arthritis. Causes include injury (leading to osteoarthritis), metabolic abnormalities (such as gout and pseudogout), hereditary factors, the direct and indirect effect of infections (bacterial and viral), and a misdirected immune system with autoimmunity (such as in rheumatoid arthritis and systemic lupus erythematosus).
A report from the American Academy of Pediatrics (AAP) published in the journal Pediatrics cautions pregnant women and nursing mothers to avoid marijuana use due to possible adverse developmental effects to their baby. In a study reviewed for the report, short-term exposure to CBD was found to increase the permeability of the placental barrier, potentially placing the fetus at risk from certain substances.
The pain of diabetic nerve damage may respond to traditional treatments with certain medications such as gabapentin (Neurontin), phenytoin (Dilantin), and carbamazepine (Tegretol) that are traditionally used in the treatment of seizure disorders. Amitriptyline (Elavil, Endep) and desipramine (Norpraminine) are medications that are traditionally used for depression. While many of these medications are not indicated specifically for the treatment of diabetes related nerve pain, they are used by physicians commonly.
Multiple national medical guidelines recommend early palliative care for patients whose cancer has produced distressing symptoms or who need help coping with their illness. In patients first diagnosed with metastatic disease, palliative care may be immediately indicated. Palliative care is indicated for patients with a prognosis of less than 12 months of life even given aggressive treatment.[158][159][160]
Cross-sectional studies have found a direct correlation between more severe PTSD symptomatology and increased motivation to use cannabis for coping purposes, especially among patients with difficulties in emotional regulation or stress tolerance. When using cannabis treatment, military veterans with PTSD reported reduced anxiety and insomnia and improved coping ability. (5)
Georgia’s law is much more limited than some other states’ medical marijuana laws. For example, it does not legalize the sale or possession of marijuana in leaf form, and it does not authorize retail stores to sell marijuana or products made from the marijuana plant. It does not authorize physicians to prescribe marijuana for medical use. It is intended solely to protect qualified persons from criminal prosecution for possessing low THC oil for medicinal purposes. 
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Bonn-Miller also explained that it's imperative to exhaust the traditional and established front-line treatments that are available before seeking out these products. "CBD is not really a first-line treatment for anything," he said. "You don’t want situations where somebody says, 'I have cancer I'm going to forgo chemotherapy because I read something about CBD or THC helping with cancer.'" That's not a good idea, Bonn-Miller said. "Not only is the science not there, but you may end up worse off."
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