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A review published in 2017 in the journal Frontiers in Pharmacology described how CBD may work to protect the hippocampus — the part of the brain responsible for several important functions, such as learning, memory and navigation — during times of stress, and may also help prevent brain-cell destruction that results from schizophrenia. Another 2017 review published in the journal Annals of Palliative Medicine summarized a handful of studies that suggest cannabis oils containing THC or CBD, or both, may help with chronic pain management, but the mechanism is unclear.
While CBD is considered the major non-psychoactive component of cannabis, in studies using varied doses, routes of administration, and combination or whole products with THC, a number of side effects have been reported, including anxiety, changes in appetite and mood, diarrhea, dizziness, drowsiness, dry mouth, low blood pressure, mental confusion, nausea, and vomiting.
"Total joint replacement" is a surgical procedure whereby a destroyed joint is replaced with artificial materials. For example, the small joints of the hand can be replaced with plastic material. Large joints, such as the hips or knees, are replaced with metals. Total hip and total knee replacements are now commonplace. These can bring dramatic pain relief and improved function.
CBD and the other plant cannabinoids are chemically classified as “terpenophenolic” compounds. To the non-scientists among us, this means that CBD is soluble in both oil and alcohol. Thus, the process of extracting CBD oil from cannabis often entails the use of a solvent that’s good at dissolving an oil or an alcohol-based compound. Solvents that are commonly used to extract CBD from cannabis include supercritical CO2, ethanol, hydrocarbons (such as butane) and olive oil.

A report from the American Academy of Pediatrics (AAP) published in the journal Pediatrics cautions pregnant women and nursing mothers to avoid marijuana use due to possible adverse developmental effects to their baby. In a study reviewed for the report, short-term exposure to CBD was found to increase the permeability of the placental barrier, potentially placing the fetus at risk from certain substances.

While joint symptoms are considered the primary characteristic of arthritis, certain rheumatic diseases may affect parts of the body other than the joints. For example, connective tissue (found in tendons, muscles, or skin) can be affected. Certain rheumatic conditions may also affect internal organs. The extra-articular manifestations and systemic effects may result in debilitating or even life-threatening complications.
We all know of Charlotte’s Web; the miracle strain that is packed with a high concentration of CBD. The Charlotte’s Web Cannabis Strain was named after Charlotte Figi, who suffers from Dravet syndrome and was experiencing several seizures daily until the Stanley Brothers came up with this powerful strain. Since then, Charlotte’s web has been morphed into various products, including their famous Charlotte’s Web CBD oil.
I have idiopathic peripheral neuropathy ... the only thing they found that would work is lyrica. I picked up some CBD oil yesterday morning. I am prescribed to take 75 mg of lyrica 3x per day. I took one yesterday morning and have only used the CBD oil since. I bought the Koi brand, flavored, 250 MG. I used a full dropper yesterday late morning and a full dropper yesterday late afternoon. I used it once today (one full dropper) and I am amazingly pain free.

Type 2 diabetes: Type 2 diabetes affects the way the body uses insulin. While the body still makes insulin, unlike in type I, the cells in the body do not respond to it as effectively as they once did. This is the most common type of diabetes, according to the National Institute of Diabetes and Digestive and Kidney Diseases, and it has strong links with obesity.


Answering the question “what is CBD oil” would be incomplete without mentioning the many CBD oil benefits. In addition to positively affecting the endocannabinoid system, CBD has been the focus of more than 23,000 published studies about cannabinoids in relation to various medical indications including anxiety, epilepsy, inflammation, cancer and chronic pain to name few. You can even find CBD for pets that is specially formulated to safely allow your pets to experience the natural benefits of CBD. For a more comprehensive look at these and other studies, visit our medical research and education page. Stay up-to-date on the latest developments in CBD and cannabis in our medical marijuana news section.
Zuardi, A. W., Crippa, J. A., Hallak, J. E., Bhattacharyya, S., Atakan, Z., Martin-Santos, R., … & Guimarães, F. S. (2012). A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation [Abstract]. Current Pharmaceutical Design, 18(32), 5,131–5,140. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22716160

Generalized pain, for instance, has dozens upon dozens of high profile research and clinical studies that have been carried out in universities and laboratories around the globe. One of the most well-publicized of these studies took place back in 2008, in which results determined that “cannabinoid analgesics (pain relievers) have generally been well tolerated in clinical trials … with acceptable adverse event profiles (meaning acceptable effectiveness for practical use).
Some substances cause cancer primarily through their physical, rather than chemical, effects.[63] A prominent example of this is prolonged exposure to asbestos, naturally occurring mineral fibers that are a major cause of mesothelioma (cancer of the serous membrane) usually the serous membrane surrounding the lungs.[63] Other substances in this category, including both naturally occurring and synthetic asbestos-like fibers, such as wollastonite, attapulgite, glass wool and rock wool, are believed to have similar effects.[63] Non-fibrous particulate materials that cause cancer include powdered metallic cobalt and nickel and crystalline silica (quartz, cristobalite and tridymite).[63] Usually, physical carcinogens must get inside the body (such as through inhalation) and require years of exposure to produce cancer.[63]

In 2015, about 90.5 million people had cancer.[6] About 14.1 million new cases occur a year (not including skin cancer other than melanoma).[11] It caused about 8.8 million deaths (15.7% of deaths).[7] The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer and stomach cancer.[19] In females, the most common types are breast cancer, colorectal cancer, lung cancer and cervical cancer.[11] If skin cancer other than melanoma were included in total new cancer cases each year, it would account for around 40% of cases.[20][21] In children, acute lymphoblastic leukemia and brain tumors are most common, except in Africa where non-Hodgkin lymphoma occurs more often.[18] In 2012, about 165,000 children under 15 years of age were diagnosed with cancer.[19] The risk of cancer increases significantly with age, and many cancers occur more commonly in developed countries.[11] Rates are increasing as more people live to an old age and as lifestyle changes occur in the developing world.[22] The financial costs of cancer were estimated at $1.16 trillion USD per year as of 2010.[23]
Ethanol extracts available in medical cannabis dispensaries are typically referred to as Rick Simpson Oil (aka RSO) or Full-Extract Cannabis Oil (FECO). In order to make RSO or FECO, cannabis flower is soaked in ethanol, agitated, and strained; then the residual oil is gently heated until all that remains is a viscous, highly concentrated goo infused with cannabinoids, which can be difficult to dose accurately, given how thick it is.
The term "diabetes" or "to pass through" was first used in 230 BCE by the Greek Apollonius of Memphis.[108] The disease was considered rare during the time of the Roman empire, with Galen commenting he had only seen two cases during his career.[108] This is possibly due to the diet and lifestyle of the ancients, or because the clinical symptoms were observed during the advanced stage of the disease. Galen named the disease "diarrhea of the urine" (diarrhea urinosa).[110]
Not included in the above types listed are metastatic cancers; this is because metastatic cancer cells usually arise from a cell type listed above and the major difference from the above types is that these cells are now present in a tissue from which the cancer cells did not originally develop. Consequently, if the terms "metastatic cancer" is used, for accuracy, the tissue from which the cancer cells arose should be included. For example, a patient may say they have or are diagnosed with "metastatic cancer" but the more accurate statement is "metastatic (breast, lung, colon, or other type) cancer with spread to the organ in which it has been found." Another example is the following: A doctor describing a man whose prostate cancer has spread to his bones should say the man has metastatic prostate cancer to bone. This is not "bone cancer," which would be cancer that started in the bone cells. Metastatic prostate cancer to bone is treated differently than lung cancer to bone.

Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.
The outlook for patients with arthritis depends on its severity, complications, and whether or not there are non-joint manifestations of the disease. For example, rheumatoid arthritis can affect the lungs, kidneys, eyes, etc. Chronic joint inflammation can lead to permanent damage to the joint and loss of joint function, making movement difficult or impossible.
Rheumatologists have particular skills in the evaluation of the over 100 forms of arthritis and have special interests in inflammatory arthritis such as rheumatoid arthritis, seronegative arthritis, spondylitis, psoriatic arthritis, systemic lupus erythematosus, antiphospholipid syndrome, Still's disease, dermatomyositis, Sjögren's syndrome, vasculitis, scleroderma, mixed connective tissue disease, sarcoidosis, Lyme disease, osteomyelitis, osteoarthritis, back pain, gout, pseudogout, relapsing polychondritis, Henoch-Schönlein purpura, serum sickness, reactive arthritis, Kawasaki disease, fibromyalgia, erythromelalgia, Raynaud's disease, growing pains, iritis, osteoporosis, reflex sympathetic dystrophy, and others.
Cancer - the Brave Crab Sent to this Earth by something they believe in, only to mess with someone bigger than they are, this isn't an animal aware of their strength. Patriotism can make them endanger their own wellbeing, fighting for someone else's cause, as if others can become their higher power. The Crab knows where they're going, but this is often in a wrong direction, at least until they learn their lessons and start relying solely on themselves.
CO2 extraction. The supercritical (or subcritical) CO2 method uses carbon dioxide under high pressure and extremely low temperatures to isolate, preserve, and maintain the purity of the medicinal oil. This process requires expensive equipment and a steep operational learning curve. But, when done well the end product is safe, potent, and free of chlorophyll.
The transformation of a normal cell into cancer is akin to a chain reaction caused by initial errors, which compound into more severe errors, each progressively allowing the cell to escape more controls that limit normal tissue growth. This rebellion-like scenario is an undesirable survival of the fittest, where the driving forces of evolution work against the body's design and enforcement of order. Once cancer has begun to develop, this ongoing process, termed clonal evolution, drives progression towards more invasive stages.[76] Clonal evolution leads to intra-tumour heterogeneity (cancer cells with heterogeneous mutations) that complicates designing effective treatment strategies.

12 September 2018 – The International Agency for Research on Cancer (IARC) today released the latest estimates on the global burden of cancer. The GLOBOCAN 2018 database, accessible online as part of the IARC Global Cancer Observatory, provides estimates of incidence and mortality in 185 countries for 36 types of cancer and for all cancer sites combined. An analysis of these results, published today in CA: A Cancer Journal for Clinicians, highlights the large geographical diversity in cancer occurrence and the variations in the magnitude and profile of the disease between and within world regions.
The tricky part is that there's some evidence suggesting CBD works best for pain when combined with a little THC, says Dr. Danesh. "Depending on what type of pain you have, you might be able to do just CBD, but sometimes you need CBD and THC." This makes accessing a product that will actually help you more difficult due to different regulations in each state. In New York, where Dr. Danesh practices, for example, CBD is available over the counter. But as soon as you add THC, you need a prescription.
Hormones are important agents in sex-related cancers, such as cancer of the breast, endometrium, prostate, ovary and testis and also of thyroid cancer and bone cancer.[69] For example, the daughters of women who have breast cancer have significantly higher levels of estrogen and progesterone than the daughters of women without breast cancer. These higher hormone levels may explain their higher risk of breast cancer, even in the absence of a breast-cancer gene.[69] Similarly, men of African ancestry have significantly higher levels of testosterone than men of European ancestry and have a correspondingly higher level of prostate cancer.[69] Men of Asian ancestry, with the lowest levels of testosterone-activating androstanediol glucuronide, have the lowest levels of prostate cancer.[69]

Decreased mobility, in combination with the above symptoms, can make it difficult for an individual to remain physically active, contributing to an increased risk of obesity, high cholesterol or vulnerability to heart disease.[24] People with arthritis are also at increased risk of depression, which may be a response to numerous factors, including fear of worsening symptoms.[25]


The side effects and risks involved with consuming marijuana-based products aren't clear, either, Bonn-Miller said. It's important to "determine cannabinoids that are useful therapeutically while understanding and using cannabinoids that are associated with less risk," he said. At least with CBD, he said, it doesn't appear to have the potential for addiction. That's different from THC, which has been associated with addiction, he said, and negative side effects, including acute anxiety.
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