Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
Many people who suffer from arthritis experience either severe chronic pain or moderate chronic pain with occasional episodes of severe pain. Since the degree of pain and disability is highly influenced by an individual's perception of pain and not necessarily correlated with the degree of cartilage degeneration, a treatment plan that includes both conventional and integrative therapies can be very effective. As always, you should make sure that you communicate and share your treatment plan with all of your care providers.
A wealth of marketing material, blogs and anecdotes claim that cannabis oils can cure whatever ails you, even cancer. But the limited research doesn't suggest that cannabis oil should take the place of conventional medication, except for in two very rare forms of epilepsy (and even then, it's recommended only as a last-resort treatment). And, experts caution that because cannabis oil and other cannabis-based products are not regulated or tested for safety by the government or any third-party agency, it's difficult for consumers to know exactly what they're getting.
Medications can be used to prevent cancer in a few circumstances. In the general population, NSAIDs reduce the risk of colorectal cancer; however, due to cardiovascular and gastrointestinal side effects, they cause overall harm when used for prevention. Aspirin has been found to reduce the risk of death from cancer by about 7%. COX-2 inhibitors may decrease the rate of polyp formation in people with familial adenomatous polyposis; however, it is associated with the same adverse effects as NSAIDs. Daily use of tamoxifen or raloxifene reduce the risk of breast cancer in high-risk women. The benefit versus harm for 5-alpha-reductase inhibitor such as finasteride is not clear.
*Seeds may only be germinated in countries/areas where it is legally permitted. In the United States & parts of the EU these seeds are for use as a collection piece, pet food, fishing bait or novelty item only. We do not endorse and actively discourage people from breaking their local laws. It is the buyer's responsibility to check these items are in accordance with their localised legislation.
^ Nadulski T, Pragst F, Weinberg G, Roser P, Schnelle M, Fronk EM, Stadelmann AM (December 2005). "Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract". Ther Drug Monit. 27 (6): 799–810. doi:10.1097/01.ftd.0000177223.19294.5c. PMID 16306858.
The ACMPR requires that all Licensed Producers display total levels of potential THC and CBD on their product labels. Total potential THC is the total amount of THC available when all THCa (tetrahydrocannabinolic acid) is decarboxylated. Total potential CBD is the total of CBD available when all the CBDa (Cannabidiolic acid) is decarboxylated. Learn more about decarboxylation here.
Can CBD oil help anxiety? Cannabidiol (CBD) is a chemical occurring in cannabis plants. It is possible to add CBD oil to food, and an increasing amount of evidence suggests that it may improve mental health, particularly anxiety. It does not seem to have adverse side effects, but CBD oil is illegal in some states. Learn more about CBD oil here. Read now
In sporadic cancers, deficiencies in DNA repair are occasionally caused by a mutation in a DNA repair gene but are much more frequently caused by epigenetic alterations that reduce or silence expression of DNA repair genes. This is indicated in the figure at the 3rd level. Many studies of heavy metal-induced carcinogenesis show that such heavy metals cause a reduction in expression of DNA repair enzymes, some through epigenetic mechanisms. DNA repair inhibition is proposed to be a predominant mechanism in heavy metal-induced carcinogenicity. In addition, frequent epigenetic alterations of the DNA sequences code for small RNAs called microRNAs (or miRNAs). miRNAs do not code for proteins, but can "target" protein-coding genes and reduce their expression.
Figuring out how much CBD oil to take can feel like trying to navigate through a complicated maze. The sheer volume of CBD brands on the market can create confusion for consumers, and when you take a closer look, it’s not difficult to understand why. Not only do vendors use different source materials (CBD-rich cannabis vs. industrial hemp, different strains, etc.), but they also implement different extraction techniques .
Worsening of joint symptoms: This includes more pain, more swelling, additional joint involvement, redness, stiffness, or limitation of function. The doctor will determine whether or not these are significant, not the patient. Sometimes, patients have just begun a medication and some minor increase in joint problems might be occurring while the medication is taking effect. However, worsening symptoms can also mean that the medications are not working and that they require adjustments in dosing or a change in the medications.
Vision loss of red/green color distinction: A rare complication of the commonly used rheumatoid arthritis drug hydroxychloroquine is an injury to the retina (the light-sensing portion of the back of the eye). The earliest sign of retinal changes from hydroxychloroquine is a decreased ability to distinguish between red and green colors. This occurs because the vision area of the retina that is first affected by the drug normally detects these colors. People who are taking hydroxychloroquine who lose red/green color distinction should stop the drug and contact their doctor.
To access CBD oil, a solvent extraction process is required, which returns roughly 3-5 grams of oil per ounce of flower product used. Using grain or isopropyl alcohol as a solvent, you can strain the result of the mixture, leaving CBD oil behind. It is a lengthy process, and in countries where cannabis is legal, there are many places to access high-quality CBD oil.
The LD50 for THC (Delta 9 Tetrahydrocannabinol) is not precisely known, as there have been no recorded fatalities. Hash oil can contain up to 80% THC though up to 99% with other methods of extraction. While health issues of the lungs may be exacerbated by use of hash oil, it is not known to cause side effects not already found in other preparations of cannabis.
Arthritis that is characterized by a misdirected, overactive immune system (such as rheumatoid arthritis or ankylosing spondylitis) frequently requires medications that suppress the immune system. Medications such as methotrexate (Rheumatrex, Trexall) and sulfasalazine (Azulfidine) are examples. Newer medications that target specific areas of immune activation are referred to as biologics (or biological response modifiers). Sometimes combinations of medications are used. All of these medications require diligent, regular dosing and monitoring.
How is psoriatic arthritis different from osteoarthritis? There are many different types of arthritis. Each one causes a problem in the joints, which can lead to pain or damage. Two distinct types that people often get are psoriatic arthritis and osteoarthritis. Each has its own different causes and symptoms. Learn more about the difference between them here. Read now
Bonn-Miller also explained that it's imperative to exhaust the traditional and established front-line treatments that are available before seeking out these products. "CBD is not really a first-line treatment for anything," he said. "You don’t want situations where somebody says, 'I have cancer I'm going to forgo chemotherapy because I read something about CBD or THC helping with cancer.'" That's not a good idea, Bonn-Miller said. "Not only is the science not there, but you may end up worse off."
Ive been taking CBD tincture oil for 8 months now. It has made such a positive improvement in my life. I have more energy and I feel better overall. I feel like myself after many years of an overall feeling of lethargy. After taking CBD oil for 6 months, I went to my doctor for a regular check up. All my my bloodwork test results- including A1C and cholesteral- improved. As an added bonus, I lost 25 lbs. All of this without even trying. Adding CBD to my life has given me more energy. I feel like my metabolism has improved. Nowadays, I look forward to each day as what can I do today, while before CBD, my attitude was negative and what do I have to do today. Nothing else in my life has changed. In fact, it has become more stressful due to family illness. But CBD has taken the edge off and continues to be my go-to daily supplement. I use Medterra 500mg tincture oil and take 1/2 a dropper twice a day. Everyone is different, so adjust the amount and strength until you find what works best for you. Definitely do it. Take CBD. Youll be so happy that you did.
Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, or its action, or both. Diabetes mellitus, commonly referred to as diabetes (as it will be in this article) was first identified as a disease associated with "sweet urine," and excessive muscle loss in the ancient world. Elevated levels of blood glucose (hyperglycemia) lead to spillage of glucose into the urine, hence the term sweet urine.
As with a fermented food like kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants. Changes in the weather, soil, and water can all impact the biology of the source material. While we verify Certificates of Analysis (and take many other criteria into consideration during our review process), even the most reputable five-star companies have no way to control for every variable in this organic process.
for other general statements see Smith TJ, Hillner BE (May 2011). "Bending the cost curve in cancer care". The New England Journal of Medicine. 364 (21): 2060–5. doi:10.1056/NEJMsb1013826. PMC 4042405. PMID 21612477. and Peppercorn JM, Smith TJ, Helft PR, Debono DJ, Berry SR, Wollins DS, Hayes DM, Von Roenn JH, Schnipper LE (February 2011). "American society of clinical oncology statement: toward individualized care for patients with advanced cancer". Journal of Clinical Oncology. 29 (6): 755–60. doi:10.1200/JCO.2010.33.1744. PMID 21263086.
Kimberly is the reference editor for Live Science and Space.com. She has a bachelor's degree in marine biology from Texas A&M University, a master's degree in biology from Southeastern Louisiana University and a graduate certificate in science communication from the University of California, Santa Cruz. Her favorite stories include animals and obscurities. A Texas native, Kim now lives in a California redwood forest. You can follow her on Twitter @kimdhickok.