The equivalency factor is not designed to compare the effects of cannabis oil to dried cannabis, or provide dosage information. For many patients, consuming cannabis orally will produce much stronger effects than inhaling it. For example, when considering a product that has an equivalency factor of 12ml of oil to 1 gram of dried cannabis, and a patient who usually consumes 1 gram of dried product a day, this patient will likely use less than 12 ml of oil per day. Even for patients who have previous experience of using cannabis oil, it is recommend that you start with a low dose and go slow.
The first WHO Global report on diabetes demonstrates that the number of adults living with diabetes has almost quadrupled since 1980 to 422 million adults. Factors driving this dramatic rise, which is largely on account of type 2 diabetes, include overweight and obesity. The new report calls upon governments to ensure that people are able to make healthy choices and that health systems are able to diagnose, treat and care for people with diabetes.
In patients with type 2 diabetes, stress, infection, and medications (such as corticosteroids) can also lead to severely elevated blood sugar levels. Accompanied by dehydration, severe blood sugar elevation in patients with type 2 diabetes can lead to an increase in blood osmolality (hyperosmolar state). This condition can worsen and lead to coma (hyperosmolar coma). A hyperosmolar coma usually occurs in elderly patients with type 2 diabetes. Like diabetic ketoacidosis, a hyperosmolar coma is a medical emergency. Immediate treatment with intravenous fluid and insulin is important in reversing the hyperosmolar state. Unlike patients with type 1 diabetes, patients with type 2 diabetes do not generally develop ketoacidosis solely on the basis of their diabetes. Since in general, type 2 diabetes occurs in an older population, concomitant medical conditions are more likely to be present, and these patients may actually be sicker overall. The complication and death rates from hyperosmolar coma is thus higher than in diabetic ketoacidosis.

And the products on the shelf aren't all the same, Ward said. "There can be many, many different varieties, and if you're thinking about doing this for medical reasons, you want to find a trusted source and do your research," she said. "Where does that oil come from, and how confident can you be that you know the exact percentages of the different cannabinoids in the product?"
Pharmaceutical companies producing oils are subject to a pharmaceutical production licence for controlled drugs, issued by government regulators. Currently there are no pharmaceutical companies producing cannabis oil as a medicine. This might change in the future when a standardised, GMP-certified production method becomes available, setting the standards for the production of cannabis oil as a pharmaceutical product.

Multiple national medical guidelines recommend early palliative care for patients whose cancer has produced distressing symptoms or who need help coping with their illness. In patients first diagnosed with metastatic disease, palliative care may be immediately indicated. Palliative care is indicated for patients with a prognosis of less than 12 months of life even given aggressive treatment.[158][159][160]


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CBD and the other plant cannabinoids are chemically classified as “terpenophenolic” compounds. To the non-scientists among us, this means that CBD is soluble in both oil and alcohol. Thus, the process of extracting CBD oil from cannabis often entails the use of a solvent that’s good at dissolving an oil or an alcohol-based compound. Solvents that are commonly used to extract CBD from cannabis include supercritical CO2, ethanol, hydrocarbons (such as butane) and olive oil.
Methyl Sulfonyl Methane (MSM) has a metabolite that is found naturally in the human body, and is commonly found in green vegetables, garlic, onions, fruits, grains, algae, and milk. It is an important source of sulfur, required for the synthesis of cartilage.  Animal studies suggest MSM decreases inflammatory joint disease, but human studies have not been done. Usual dose is 1000 to 3000 mg three times a day. There may be side effects of nausea, diarrhea, and headaches.
Marijuana enthusiasts will always hold a special place in their heart for the big, beautiful, healthy bud cut fresh from plant ready for a good ole fashioned smoke. However, since the passage of medical and recreational marijuana in Colorado, cannabis consumption methods have evolved rapidly and the popularity of concentrated hash oil products has surged.
Insulin is a hormone that is produced by specialized cells (beta cells) of the pancreas. (The pancreas is a deep-seated organ in the abdomen located behind the stomach.) In addition to helping glucose enter the cells, insulin is also important in tightly regulating the level of glucose in the blood. After a meal, the blood glucose level rises. In response to the increased glucose level, the pancreas normally releases more insulin into the bloodstream to help glucose enter the cells and lower blood glucose levels after a meal. When the blood glucose levels are lowered, the insulin release from the pancreas is turned down. It is important to note that even in the fasting state there is a low steady release of insulin than fluctuates a bit and helps to maintain a steady blood sugar level during fasting. In normal individuals, such a regulatory system helps to keep blood glucose levels in a tightly controlled range. As outlined above, in patients with diabetes, the insulin is either absent, relatively insufficient for the body's needs, or not used properly by the body. All of these factors cause elevated levels of blood glucose (hyperglycemia).
While there is a strong genetic component to developing this form of diabetes, there are other risk factors - the most significant of which is obesity. There is a direct relationship between the degree of obesity and the risk of developing type 2 diabetes, and this holds true in children as well as adults. It is estimated that the chance to develop diabetes doubles for every 20% increase over desirable body weight.
Periodontal disease is the most common dental disease affecting those living with diabetes, affecting nearly 22% of those diagnosed. Especially with increasing age, poor blood sugar control increases the risk for gum problems.  In fact, people with diabetes are at a higher risk for gum problems because of poor blood sugar control. As with all infections, serious gum disease may cause blood sugar to rise. This makes diabetes harder to control because you are more susceptible to infections and are less able to fight the bacteria invading the gums.
Diabetes experts feel that these blood glucose monitoring devices give patients a significant amount of independence to manage their disease process; and they are a great tool for education as well. It is also important to remember that these devices can be used intermittently with fingerstick measurements. For example, a well-controlled patient with diabetes can rely on fingerstick glucose checks a few times a day and do well. If they become ill, if they decide to embark on a new exercise regimen, if they change their diet and so on, they can use the sensor to supplement their fingerstick regimen, providing more information on how they are responding to new lifestyle changes or stressors. This kind of system takes us one step closer to closing the loop, and to the development of an artificial pancreas that senses insulin requirements based on glucose levels and the body's needs and releases insulin accordingly - the ultimate goal.
Cancer is a generic term for a large group of diseases characterized by the growth of abnormal cells beyond their usual boundaries that can then invade adjoining parts of the body and/or spread to other organs. Other common terms used are malignant tumours and neoplasms. Cancer can affect almost any part of the body and has many anatomic and molecular subtypes that each require specific management strategies.
The classic symptoms of untreated diabetes are unintended weight loss, polyuria (increased urination), polydipsia (increased thirst), and polyphagia (increased hunger).[20] Symptoms may develop rapidly (weeks or months) in type 1 DM, while they usually develop much more slowly and may be subtle or absent in type 2 DM. Other symptoms of diabetes mellitus include weight loss and tiredness.[21]
31 January 2019 ¦ GENEVA: Ahead of World Cancer Day (4 February), the World Health Organization (WHO) has released new guidance on managing cancer pain, with a view to improving the health sector response and ending the needless suffering of cancer patients. Around the world, pain is experienced by more than half (55%) of patients undergoing treatment for cancer and two thirds (66%) of people with advanced or terminal cancer. The WHO Guidelines for the pharmacologic and radiotherapeutic management of cancer pain in adults and adolescents provide evidence-based guidance to health-care providers on appropriate approaches to the medical and radiotherapeutic management of cancer pain. This includes guidance on the choice of analgesic medicines (painkillers); the use of adjuvant medicines (steroids), and specific techniques for treating pain from bone metastases (bisphosphonates and radiotherapy).
Psoriasis can develop into psoriatic arthritis. With psoriatic arthritis, most individuals develop the skin problem first and then the arthritis. The typical features are of continuous joint pains, stiffness and swelling. The disease does recur with periods of remission but there is no cure for the disorder. A small percentage develop a severe painful and destructive form of arthritis which destroys the small joints in the hands and can lead to permanent disability and loss of hand function.[41]
Amino acids are required for cell survival and growth. However, the different requirements of amino acid metabolic pathways in normal haematopoiesis and leukaemogenesis have not been explored. Here the authors focus on the transporter of neutral amino acids and show that malignant blood cells rely more on ASCT2-mediated amino acid metabolism than normal cells.
^ Ideguchi, Haruko; Ohno, Shigeru; Hattori, Hideaki; Senuma, Akiko; Ishigatsubo, Yoshiaki (2006). "Bone erosions in rheumatoid arthritis can be repaired through reduction in disease activity with conventional disease-modifying antirheumatic drugs". Arthritis Research & Therapy. 8 (3): R76. doi:10.1186/ar1943. ISSN 1478-6354. PMC 1526642. PMID 16646983.
The side effects and risks involved with consuming marijuana-based products aren't clear, either, Bonn-Miller said. It's important to "determine cannabinoids that are useful therapeutically while understanding and using cannabinoids that are associated with less risk," he said. At least with CBD, he said, it doesn't appear to have the potential for addiction. That's different from THC, which has been associated with addiction, he said, and negative side effects, including acute anxiety.
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