Ankylosing spondylitis, a chronic inflammatory disease of the spine, can cause the vertebrae to fuse, producing a rigid spine. Other joints, besides the spine, may become involved. The exact cause is still unknown, but most people with spondylitis have a genetic marker, known as HLA-B27. Having this genetic marker does not guarantee that a person will develop spondylitis, but people with the marker have a greater risk. Ankylosing spondylitis usually affects men between the ages of 16 and 35, but it can also affect women.
Ten US states have legalized use of recreational marijuana as of November 2018. In 2012, voters in Colorado and Washington state passed initiatives legalizing cannabis for adults 21 and older under state law. In November 2014, Oregon, Alaska, and Washington D.C also approved recreational use of marijuana. In November 2016, four more states - California, Massachusetts, Maine, and Nevada - voted in recreational marijuana. On July 1, 2018 Vermont began allowing recreational use. In 2018, Michigan voted to legalize pot for recreational use, but a measure in North Dakota failed.
For another type of dietary supplementation, it should be noted that fish oils have been shown to have some anti-inflammation properties. Moreover, increasing the dietary fish intake and/or fish oil capsules (omega-3 capsules) can sometimes reduce the inflammation of arthritis. Obesity has long been known to be a risk factor for osteoarthritis of the knee. Weight reduction is recommended for patients who are overweight and have early signs of osteoarthritis of the hands, because they are at a risk for also developing osteoarthritis of their knees. Of note, even modest weight reduction can be helpful.
In autoimmune diseases, such as type 1 diabetes, the immune system mistakenly manufactures antibodies and inflammatory cells that are directed against and cause damage to patients' own body tissues. In persons with type 1 diabetes, the beta cells of the pancreas, which are responsible for insulin production, are attacked by the misdirected immune system. It is believed that the tendency to develop abnormal antibodies in type 1 diabetes is, in part, genetically inherited, though the details are not fully understood.
This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

The most prodigious source of cannabidiol are high-resin CBD-rich cannabis plants that tip the scales at 20 percent CBD by dry weight and around one percent THC. Unfortunately, under the current legal regime that’s too much THC to qualify as hemp, even though anyone who smoked the resinous flower tops wouldn’t get high because CBD is not intoxicating like THC. It can, however, do a person a world of good if they are struggling with pain or anxiety or depression.
There is no known cure for either rheumatoid or osteoarthritis. Treatment options vary depending on the type of arthritis and include physical therapy, lifestyle changes (including exercise and weight control), orthopedic bracing, and medications. Joint replacement surgery may be required in eroding forms of arthritis. Medications can help reduce inflammation in the joint which decreases pain. Moreover, by decreasing inflammation, the joint damage may be slowed.[citation needed]
In 1937, the U.S. Treasury Department introduced the Marihuana Tax Act, which imposed a levy of $1 per ounce for medicinal use of cannabis and $100 per ounce for recreational use. This was opposed by physicians who were not required to pay a special tax for prescribing cannabis, use special order forms to obtain it and keep records detailing its professional use. The American Medical Association believed that evidence of cannabis’ harmful effects was limited and the act would prevent further research into its medicinal worth.

Third-party testing: Once a CBD oil is manufactured, CBD oil companies will often submit their products for third-party tests, which are conducted by non-company personnel to ensure the product is safe for public consumption and meets quality standards.CBD oils should always be accompanied with information about third-party tests; best practice is to avoid oils that do not supply these details.
For another type of dietary supplementation, it should be noted that fish oils have been shown to have some anti-inflammation properties. Moreover, increasing the dietary fish intake and/or fish oil capsules (omega-3 capsules) can sometimes reduce the inflammation of arthritis. Obesity has long been known to be a risk factor for osteoarthritis of the knee. Weight reduction is recommended for patients who are overweight and have early signs of osteoarthritis of the hands, because they are at a risk for also developing osteoarthritis of their knees. Of note, even modest weight reduction can be helpful.

31 January 2019 ¦ GENEVA: Ahead of World Cancer Day (4 February), the World Health Organization (WHO) has released new guidance on managing cancer pain, with a view to improving the health sector response and ending the needless suffering of cancer patients. Around the world, pain is experienced by more than half (55%) of patients undergoing treatment for cancer and two thirds (66%) of people with advanced or terminal cancer. The WHO Guidelines for the pharmacologic and radiotherapeutic management of cancer pain in adults and adolescents provide evidence-based guidance to health-care providers on appropriate approaches to the medical and radiotherapeutic management of cancer pain. This includes guidance on the choice of analgesic medicines (painkillers); the use of adjuvant medicines (steroids), and specific techniques for treating pain from bone metastases (bisphosphonates and radiotherapy).
In fact, the U.S. Food and Drug Administration (FDA) approved Epidiolex (a drug made with a purified form of CBD oil) in June 2018 for the treatment of seizures associated with two rare and severe forms of epilepsy in patients 2 years of age and older. These two epilepsy forms are known as Lennox-Gastaut syndrome and Dravet syndrome. Epidiolex is the first FDA-approved drug that contains a purified drug substance derived from marijuana.
This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor’s advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Individual weight loss results will vary. By using this site you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited By Law.
When exposed to air, warmth and light (especially without antioxidants), the oil loses its taste and psychoactivity due to aging. Cannabinoid carboxylic acids (THCA, CBDA, and maybe others) have an antibiotic effect on gram-positive bacteria such as (penicillin-resistant) Staphylococcus aureus, but gram-negative bacteria such as Escherichia coli are unaffected.[26]
In 2015, about 90.5 million people had cancer.[6] About 14.1 million new cases occur a year (not including skin cancer other than melanoma).[11] It caused about 8.8 million deaths (15.7% of deaths).[7] The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer and stomach cancer.[19] In females, the most common types are breast cancer, colorectal cancer, lung cancer and cervical cancer.[11] If skin cancer other than melanoma were included in total new cancer cases each year, it would account for around 40% of cases.[20][21] In children, acute lymphoblastic leukemia and brain tumors are most common, except in Africa where non-Hodgkin lymphoma occurs more often.[18] In 2012, about 165,000 children under 15 years of age were diagnosed with cancer.[19] The risk of cancer increases significantly with age, and many cancers occur more commonly in developed countries.[11] Rates are increasing as more people live to an old age and as lifestyle changes occur in the developing world.[22] The financial costs of cancer were estimated at $1.16 trillion USD per year as of 2010.[23]

The environment around you may contain harmful chemicals that can increase your risk of cancer. Even if you don't smoke, you might inhale secondhand smoke if you go where people are smoking or if you live with someone who smokes. Chemicals in your home or workplace, such as asbestos and benzene, also are associated with an increased risk of cancer.


An anti-inflammatory diet—that is, one low in saturated fats like red meat, dairy, and fried food—may help reduce the inflammatory process in the joints. Increasing Omega-3 fatty acids may also help this balance. Some individuals may have symptomatic improvement with the elimination of nightshades (tomatoes, potatoes, eggplant, peppers, tobacco).  A 2-3 week trial is worth considering.

In fact, the U.S. Food and Drug Administration (FDA) approved Epidiolex (a drug made with a purified form of CBD oil) in June 2018 for the treatment of seizures associated with two rare and severe forms of epilepsy in patients 2 years of age and older. These two epilepsy forms are known as Lennox-Gastaut syndrome and Dravet syndrome. Epidiolex is the first FDA-approved drug that contains a purified drug substance derived from marijuana.


Epigenetic alterations are functionally relevant modifications to the genome that do not change the nucleotide sequence. Examples of such modifications are changes in DNA methylation (hypermethylation and hypomethylation), histone modification[78] and changes in chromosomal architecture (caused by inappropriate expression of proteins such as HMGA2 or HMGA1).[79] Each of these alterations regulates gene expression without altering the underlying DNA sequence. These changes may remain through cell divisions, last for multiple generations and can be considered to be epimutations (equivalent to mutations).
Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it can occur in many joints and be quite crippling. The joints in gout can often become swollen and lose function. Gouty arthritis can become particularly painful and potentially debilitating when gout cannot successfully be treated.[35] When uric acid levels and gout symptoms cannot be controlled with standard gout medicines that decrease the production of uric acid (e.g., allopurinol, febuxostat) or increase uric acid elimination from the body through the kidneys (e.g., probenecid), this can be referred to as refractory chronic gout or RCG.[36]
Before beginning any treatment, it is important that you consult your healthcare provider and be open and honest about your plans. Having a strong doctor-patient relationship is key to establishing trust and determining an effective treatment plan that takes into account your lifestyle. “These drugs do interact with the body,” Dr. Silberstein says. “If you’re getting funny symptoms and you’re taking something that the doctor doesn’t know about, how’s he going to help you?”
Radiation therapy involves the use of ionizing radiation in an attempt to either cure or improve symptoms. It works by damaging the DNA of cancerous tissue, killing it. To spare normal tissues (such as skin or organs, which radiation must pass through to treat the tumor), shaped radiation beams are aimed from multiple exposure angles to intersect at the tumor, providing a much larger dose there than in the surrounding, healthy tissue. As with chemotherapy, cancers vary in their response to radiation therapy.[151][152][153]
Liquid CBD Oil/Tinctures/Extracts: Drops or tinctures should have a “suggested serving size” and the total milligrams of CBD listed on their packaging. From there, you can determine the amount of CBD you would like to ingest. Simply place the correct quantity of drops under your tongue using the dropper and hold the CBD oil in place for a minimum of 60 seconds. The 60 second hold allows for absorption via the blood vessels underneath your tongue – efficiently bypassing first-pass metabolism. Once 60 seconds has passed, swallow the CBD oil.
Effective therapy can prevent or delay diabetic complications.1,2 However, about 28 percent of Americans with DM are undiagnosed, and another 86 million American adults have blood glucose levels that greatly increase their risk of developing type 2 DM in the next several years.3 Diabetes complications tend to be more common and more severe among people whose diabetes is poorly controlled, which makes DM an immense and complex public health challenge. Preventive care practices are essential to better health outcomes for people with diabetes.4
Joint pain can be caused by injury affecting any of the ligaments, bursae, or tendons surrounding the joint. Injury can also affect the ligaments, cartilage, and bones within the joint. Pain is also a feature of joint inflammation (arthritis, such as rheumatoid arthritis and osteoarthritis) and infection, and extremely rarely it can be a cause of cancer of the joint.
Per the WHO, people with fasting glucose levels from 6.1 to 6.9 mmol/l (110 to 125 mg/dl) are considered to have impaired fasting glucose.[67] people with plasma glucose at or above 7.8 mmol/l (140 mg/dl), but not over 11.1 mmol/l (200 mg/dl), two hours after a 75 gram oral glucose load are considered to have impaired glucose tolerance. Of these two prediabetic states, the latter in particular is a major risk factor for progression to full-blown diabetes mellitus, as well as cardiovascular disease.[68] The American Diabetes Association (ADA) since 2003 uses a slightly different range for impaired fasting glucose of 5.6 to 6.9 mmol/l (100 to 125 mg/dl).[69]

Anna Syreeni, Niina Sandholm, Jingjing Cao, Iiro Toppila, David M. Maahs, Marian J. Rewers, Janet K. Snell-Bergeon, Tina Costacou, Trevor J. Orchard, M. Luiza Caramori, Michael Mauer, Barbara E.K. Klein, Ronald Klein, Erkka Valo, Maija Parkkonen, Carol Forsblom, Valma Harjutsalo, Andrew D. Paterson, for the DCCT/EDIC Research Group and Per-Henrik Groop, on behalf of the FinnDiane Study Group


Industrial hemp, on the other hand, comes from the engineered Cannabis Sativa strain, which contains only trace concentrations of THC. Although hemp falls under the cannabis category, it’s different from the cannabis plant that’s grown for medicinal or recreational purposes. CBD from industrial hemp doesn’t produce the euphoric buzz that’s commonly associated with intake of marijuana-based CBD oil.
The pain of diabetic nerve damage may respond to traditional treatments with certain medications such as gabapentin (Neurontin), phenytoin (Dilantin), and carbamazepine (Tegretol) that are traditionally used in the treatment of seizure disorders. Amitriptyline (Elavil, Endep) and desipramine (Norpraminine) are medications that are traditionally used for depression. While many of these medications are not indicated specifically for the treatment of diabetes related nerve pain, they are used by physicians commonly.
There are two possible exceptions to this. The first is that some people, for unknown reasons, just react differently to CBD. According to Dr. Chin, about 5% of people say they feel altered after taking CBD. "Usually they're the same people who have side effects from Advil or Tylenol," she says. You never know how your body will react to any new supplement, so when taking CBD for the first time, do so safely under supervision.
Two types of diabetes were identified as separate conditions for the first time by the Indian physicians Sushruta and Charaka in 400–500 CE with one type being associated with youth and another type with being overweight.[108] The term "mellitus" or "from honey" was added by the Briton John Rolle in the late 1700s to separate the condition from diabetes insipidus, which is also associated with frequent urination.[108] Effective treatment was not developed until the early part of the 20th century, when Canadians Frederick Banting and Charles Herbert Best isolated and purified insulin in 1921 and 1922.[108] This was followed by the development of the long-acting insulin NPH in the 1940s.[108]

Typically, people who experience early signs of arthritis consult with their primary care physician or family physician. That may be appropriate for the first round of diagnostic testing. However, you may be referred to a rheumatologist for more in-depth evaluation and ongoing care. A rheumatologist is a specialist in the diagnosis and treatment of rheumatic diseases.
Some states offer cannabis for medical conditions, and this may require a medical note or proof of injury and illness. You can also join a collective, which is a group of patients who grow and share medical cannabis with each other. If you are using cannabis oil, it’s so important to make sure it’s purchased through a reputable company that sells pure and lab-tested oils. If you’re wondering how to make cannabis oil, you should first make sure this is legal in your state. Some people also like to make cannabis coconut oil, which is basically cannabis-infused coconut oil.
Glucosamine and chondroitin are substances that occur naturally in cartilage. Several studies have shown the benefit of oral glucosamine in osteoarthritis. In a systematic review, glucosamine was found to work as well or better than NSAIDS. (Although other studies have found it less effective.) Often glucosamine is used in combination with chondroitin, although studies are not clear as to whether there is added symptomatic improvement by adding chondroitin, there is suggestion that it may retard progression of the disease. These may be disease modifying agents, rather than just pain suppressing. Doses are 500 mg of glucosamine sulfate three times a day, with or without chondroitin sulfate 400 mg three times/day.  A minimum of a 6-week trial should be completed before symptomatic assessment is made.
A rheumatologist is a medical doctor who specializes in the nonsurgical treatment of rheumatic illnesses, especially arthritis. Rheumatologists have special interests in unexplained rash, fever, arthritis, anemia, weakness, weight loss, fatigue, joint or muscle pain, autoimmune disease, and anorexia. They often serve as consultants, acting like medical detectives at the request of other doctors.

Tobacco is responsible for about one in five cancer deaths worldwide[36] and about one in three in the developed world.[37] Lung cancer death rates in the United States have mirrored smoking patterns, with increases in smoking followed by dramatic increases in lung cancer death rates and, more recently, decreases in smoking rates since the 1950s followed by decreases in lung cancer death rates in men since 1990.[38][39]

Complementary and alternative cancer treatments are a diverse group of therapies, practices and products that are not part of conventional medicine.[163] "Complementary medicine" refers to methods and substances used along with conventional medicine, while "alternative medicine" refers to compounds used instead of conventional medicine.[164] Most complementary and alternative medicines for cancer have not been studied or tested using conventional techniques such as clinical trials. Some alternative treatments have been investigated and shown to be ineffective but still continue to be marketed and promoted. Cancer researcher Andrew J. Vickers stated, "The label 'unproven' is inappropriate for such therapies; it is time to assert that many alternative cancer therapies have been 'disproven'."[165]

Some substances cause cancer primarily through their physical, rather than chemical, effects.[63] A prominent example of this is prolonged exposure to asbestos, naturally occurring mineral fibers that are a major cause of mesothelioma (cancer of the serous membrane) usually the serous membrane surrounding the lungs.[63] Other substances in this category, including both naturally occurring and synthetic asbestos-like fibers, such as wollastonite, attapulgite, glass wool and rock wool, are believed to have similar effects.[63] Non-fibrous particulate materials that cause cancer include powdered metallic cobalt and nickel and crystalline silica (quartz, cristobalite and tridymite).[63] Usually, physical carcinogens must get inside the body (such as through inhalation) and require years of exposure to produce cancer.[63]


Can’t sleep? Cannabis oil also works for people with insomnia. The calming effects of the oil help people to sleep calmly, relieving issues of anxiety and restlessness. A 2015 scientific review published in the American Journal of Health-System Pharmacy found that cannabis treatment is effective for military veterans with post-traumatic stress disorder (PTSD). Research suggests that cannabinoids, the psychoactive components of unrefined cannabis, regulates neurotransmitter release and produces a wide range of central nervous system effects, including increased pleasure and alteration of memory processes.
The majority of cancers, some 90–95% of cases, are due to genetic mutations from environmental and lifestyle factors.[3] The remaining 5–10% are due to inherited genetics.[3] Environmental, as used by cancer researchers, means any cause that is not inherited genetically, such as lifestyle, economic, and behavioral factors and not merely pollution.[31] Common environmental factors that contribute to cancer death include tobacco (25–30%), diet and obesity (30–35%), infections (15–20%), radiation (both ionizing and non-ionizing, up to 10%), stress, lack of physical activity and pollution.[3][32]
The 1989 "St. Vincent Declaration"[117][118] was the result of international efforts to improve the care accorded to those with diabetes. Doing so is important not only in terms of quality of life and life expectancy but also economically – expenses due to diabetes have been shown to be a major drain on health – and productivity-related resources for healthcare systems and governments.
Glucagon is a hormone that causes the release of glucose from the liver (for example, it promotes gluconeogenesis). Glucagon can be lifesaving and every patient with diabetes who has a history of hypoglycemia (particularly those on insulin) should have a glucagon kit. Families and friends of those with diabetes need to be taught how to administer glucagon, since obviously the patients will not be able to do it themselves in an emergency situation. Another lifesaving device that should be mentioned is very simple; a medic-alert bracelet should be worn by all patients with diabetes.
Cancer can spread from its original site by local spread, lymphatic spread to regional lymph nodes or by hematogenous spread via the blood to distant sites, known as metastasis. When cancer spreads by a hematogenous route, it usually spreads all over the body. However, cancer 'seeds' grow in certain selected site only ('soil') as hypothesized in the soil and seed hypothesis of cancer metastasis. The symptoms of metastatic cancers depend on the tumor location and can include enlarged lymph nodes (which can be felt or sometimes seen under the skin and are typically hard), enlarged liver or enlarged spleen, which can be felt in the abdomen, pain or fracture of affected bones and neurological symptoms.[28]

Can’t sleep? Cannabis oil also works for people with insomnia. The calming effects of the oil help people to sleep calmly, relieving issues of anxiety and restlessness. A 2015 scientific review published in the American Journal of Health-System Pharmacy found that cannabis treatment is effective for military veterans with post-traumatic stress disorder (PTSD). Research suggests that cannabinoids, the psychoactive components of unrefined cannabis, regulates neurotransmitter release and produces a wide range of central nervous system effects, including increased pleasure and alteration of memory processes.
Hi Colleen, it's almost a year later and I'm wondering how you're doing. I'm experiencing a recurrence of Stage 3 ovarian, originally diagnosed in 2011. I've decided to get some chemo, not sold on another 6 cycles though. As a new MMJ patient, I'm still going to go through with Rick Simpson Oil (THC+CBD,) and I just joined a program with my local dispensary to get CBD capsules for $2 each when I order them at least 30 at a time. I hope you're doing well!! I'm off to do more research on dosing. **NOTE: If you have ANY experience with CBD treatment of ovarian cancer, PLEASE respond. Thank you!!
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