Epigenetic alterations are functionally relevant modifications to the genome that do not change the nucleotide sequence. Examples of such modifications are changes in DNA methylation (hypermethylation and hypomethylation), histone modification[78] and changes in chromosomal architecture (caused by inappropriate expression of proteins such as HMGA2 or HMGA1).[79] Each of these alterations regulates gene expression without altering the underlying DNA sequence. These changes may remain through cell divisions, last for multiple generations and can be considered to be epimutations (equivalent to mutations).

^ Manton K, Akushevich I, Kravchenko J (28 December 2008). Cancer Mortality and Morbidity Patterns in the U.S. Population: An Interdisciplinary Approach. Springer Science & Business Media. ISBN 978-0-387-78193-8. The term environment refers not only to air, water, and soil but also to substances and conditions at home and at the workplace, including diet, smoking, alcohol, drugs, exposure to chemicals, sunlight, ionizing radiation, electromagnetic fields, infectious agents, etc. Lifestyle, economic and behavioral factors are all aspects of our environment.
A wide variety of solvents can be used for extraction, such as chloroform, dichloromethane, petroleum ether, naphtha, benzene, butane, methanol, ethanol, isopropanol, and olive oil.[2][9] Currently, resinoids are often obtained by extraction with supercritical carbon dioxide. The alcohols extract undesirable water-soluble substances such as chlorophyll and sugars (which can be removed later by washing with water). Non-polar solvents such as benzene, chloroform and petroleum ether will not extract the water-soluble constituents of marijuana or hashish while still producing hash oil. In general, non-polar cannabis extracts taste much better than polar extracts. Alkali washing further improves the odor and taste.

When you eat, your body changes most of the food you digest into glucose (a form of sugar). A hormone called insulin allows this glucose to enter all the cells of your body. There it is used for energy. Insulin is produced by the pancreas. In someone who has type 2 diabetes, the pancreas doesn’t make enough insulin or the body’s cells can’t use insulin properly (called insulin resistance). This causes glucose to build up in your blood instead of moving into the cells. Too much glucose in the blood can lead to serious health problems that damage the blood vessels, nerves, heart, eyes, and kidneys.
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