Cancers usually arise from an assemblage of mutations and epimutations that confer a selective advantage leading to clonal expansion (see Field defects in progression to cancer). Mutations, however, may not be as frequent in cancers as epigenetic alterations. An average cancer of the breast or colon can have about 60 to 70 protein-altering mutations, of which about three or four may be "driver" mutations and the remaining ones may be "passenger" mutations.[93]


Some forms of arthritis are more of an annoyance than a serious medical problem. However, millions of people suffer daily with pain and disability from arthritis or its complications. Moreover, many of the forms of arthritis, because they are rheumatic diseases, can cause symptoms affecting various organs of the body that do not directly involve the joints.
Receptors for cannabinoids are found in the digestive, reproductive, nervous, and immune systems. Because cannabinoids interact with almost every system in our bodies, they’re often touted as a cure-all. While they’re not truly able to heal everything, they do regulate neurotransmitter function, inflammation, mitochondrial function, and metabolism.

Though it may be transient, untreated GDM can damage the health of the fetus or mother. Risks to the baby include macrosomia (high birth weight), congenital heart and central nervous system abnormalities, and skeletal muscle malformations. Increased levels of insulin in a fetus's blood may inhibit fetal surfactant production and cause infant respiratory distress syndrome. A high blood bilirubin level may result from red blood cell destruction. In severe cases, perinatal death may occur, most commonly as a result of poor placental perfusion due to vascular impairment. Labor induction may be indicated with decreased placental function. A caesarean section may be performed if there is marked fetal distress or an increased risk of injury associated with macrosomia, such as shoulder dystocia.[50]

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CBD oil is made by mixing the extracted CBD or cannabidiol from the cannabis or marijuana plant (Cannabis Sativa) with coconut or hemp seed oil. CBD oil possesses cannabidiol; while THC is psychoactive, CBD is not, thereby helping relieve pain and depression, fighting cancer, and reducing anxiety. It also improves the quality of sleep, boosts appetite, and optimizes digestion.
When i first heard about herbal remedy i never believe on such word until i found dr ehi a great traditional doctor that was introduced to me by a friend that suffered from Hepatitis B and was cure with the help of this great herbal doctor (dr ehi) so i decided to contact him for help in getting rid of my families genital herpes virus 1/2 which i did and all i was told to provide was just some useful information and some materials use in preparation of the natural cure and that i did and now i am the happiest person on earth because i am writing this testimony of mine with joy and happiness in my heart to the whole world to know that natural remedy is real because i am a living testimony of dr ehi's traditional herbal cure and i want you all to contact dr ehi via his email: shomorikaspelltemple@ yahoo. com or whatsapp him 2349035080936 or visit his website: drudebhuluspellherbaltemple. webs. com am sure he will help you too.
Another concern is about medications with which CBD might interact. This won’t be an issue with most drugs, says Sunil Kumar Aggarwal, M.D., Ph.D., a palliative medicine physician and scientist who studies cannabis and integrates it into his Seattle medical practice. The exceptions are blood thinners, IV antibiotics, and other drugs whose exact dosing is crucial and must be monitored closely, he says. (Of course, if you have a health problem, talk to your doctor before using CBD, and never take it instead of seeing your physician for a serious condition.)
Research conducted by Ethan B Russo, GW Pharmaceuticals, WA, USA, suggests that CBD oil interacts with the protein cells in the body and sends chemical signals to your brain and immune system through a number of stimuli. This helps the cells positively respond to chronic pain. This oil is regularly suggested for people with inflammation and back pain because of its painkilling quality.

There is no known preventive measure for type 1 diabetes.[2] Type 2 diabetes—which accounts for 85–90% of all cases worldwide—can often be prevented or delayed by maintaining a normal body weight, engaging in physical activity, and eating a healthy diet.[2] Higher levels of physical activity (more than 90 minutes per day) reduce the risk of diabetes by 28%.[71] Dietary changes known to be effective in helping to prevent diabetes include maintaining a diet rich in whole grains and fiber, and choosing good fats, such as the polyunsaturated fats found in nuts, vegetable oils, and fish.[72] Limiting sugary beverages and eating less red meat and other sources of saturated fat can also help prevent diabetes.[72] Tobacco smoking is also associated with an increased risk of diabetes and its complications, so smoking cessation can be an important preventive measure as well.[73]
Although both oils are generally safe for use, the main difference between hemp oil and marijuana oil comes down to the THC content, which contributes to their different side effects. Marijuana’s THC content naturally contributes to more potential side effects related to memory, learning, and general cognition, which invariably means you shouldn’t be doing anything important, operating heavy machinery, or driving after taking marijuana oil. By comparison, hemp oil has far fewer side effects. Most side effects are related to hemp oil’s high polyunsaturated fat content, which may contribute to heart disease and digestive problems, but only if you are ignoring serving recommendations.
Some treatments can interfere with the mother's ability to give birth vaginally or to breastfeed.[219] Cervical cancer may require birth by Caesarean section. Radiation to the breast reduces the ability of that breast to produce milk and increases the risk of mastitis. Also, when chemotherapy is given after birth, many of the drugs appear in breast milk, which could harm the baby.[219]
Better methods are becoming available to more accurately define which patients are more likely to develop more aggressive disease. Gene profiling, also known as gene array analysis, is being identified as a helpful method of defining which people will respond to which medications. Studies are underway that are using gene array analysis methods to determine which patients will be at more risk for more aggressive disease. Finally, genetic research and engineering is likely to bring forth many new avenues for earlier diagnosis and accurate treatment in the near future. This is all occurring because of technology improvements. We are at the threshold of tremendous improvements in the way rheumatoid arthritis is managed.
Dietary factors also influence the risk of developing type 2 DM. Consumption of sugar-sweetened drinks in excess is associated with an increased risk.[45][46] The type of fats in the diet is also important, with saturated fat and trans fats increasing the risk and polyunsaturated and monounsaturated fat decreasing the risk.[44] Eating lots of white rice, and other starches, also may increase the risk of diabetes.[47] A lack of physical activity is believed to cause 7% of cases.[48]
There was no mention of resin in the 2018 Farm Bill, which a cynic might refer to as the ‘Keep Marijuana Illegal Bill.’ To put it bluntly, the 0.3 percent THC legal limit is an arbitrary, impractical, euphoria-phobic relic of reefer madness. Although it lacks a scientific basis, it has become the latest lynchpin of cannabis prohibition, a dishonest, anachronistic policy that impedes medical discovery and blocks patient access to valuable therapeutic options, including herbal extracts with various combinations of CBD and THC.
Rheumatologists have particular skills in the evaluation of the over 100 forms of arthritis and have special interest in rheumatoid arthritis, spondylitis, psoriatic arthritis, systemic lupus erythematosus, antiphospholipid syndrome, Still's disease, dermatomyositis, Sjögren's syndrome, vasculitis, scleroderma, mixed connective tissue disease, sarcoidosis, Lyme disease, osteomyelitis, osteoarthritis, back pain, gout, pseudogout, relapsing polychondritis, Henoch-Schönlein purpura, serum sickness, reactive arthritis, Kawasaki disease, fibromyalgia, erythromelalgia, Raynaud's disease, growing pains, iritis, osteoporosis, reflex sympathetic dystrophy, and others.
Small-scale mutations include point mutations, deletions, and insertions, which may occur in the promoter region of a gene and affect its expression, or may occur in the gene's coding sequence and alter the function or stability of its protein product. Disruption of a single gene may also result from integration of genomic material from a DNA virus or retrovirus, leading to the expression of viral oncogenes in the affected cell and its descendants.

Multiple national medical guidelines recommend early palliative care for patients whose cancer has produced distressing symptoms or who need help coping with their illness. In patients first diagnosed with metastatic disease, palliative care may be immediately indicated. Palliative care is indicated for patients with a prognosis of less than 12 months of life even given aggressive treatment.[158][159][160]


Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment. Treatments that succeeded in one cancer type can be tested against other types.[211] Diagnostic tests are under development to better target the right therapies to the right patients, based on their individual biology.[212]
Lack of improvement of joint symptoms: One major purpose of seeing the doctor is to get better. The doctor knows this. If a patient with rheumatoid arthritis has seen the doctor and is started on a treatment program and is not showing improvement but is worsening, notification of the doctor is appropriate. After starting a new treatment program, it sometimes takes time for the medications, physical therapy, etc., to control the inflammation. It is up to the doctor to decide if things are on course.
Disability due to musculoskeletal disorders increased by 45% from 1990 to 2010. Of these, osteoarthritis is the fastest increasing major health condition.[57] Among the many reports on the increased prevalence of musculoskeletal conditions, data from Africa are lacking and underestimated. A systematic review assessed the prevalence of arthritis in Africa and included twenty population-based and seven hospital-based studies.[58] The majority of studies, twelve, were from South Africa. Nine studies were well-conducted, eleven studies were of moderate quality, and seven studies were conducted poorly. The results of the systematic review were as follows:

We are staunch advocates of CBD and its many, amazing, scientifically-backed uses. We are also staunch advocates of our patrons and their access to the highest quality, 100% organic CBD products around. Getting the information you need, the exact product you want, and a no hassle transaction with no attached shipping charges – that’s what we are all about.

I bought a bottle of the 3000 mg and I cannot and will not stop recommending it to anyone who will listen I am able to think much more clearly because Im not so stressed It has made a huge difference in the office I am working at. My boss is the one who told me about it after I had commented on how much easier it has been to work with her lately. I am so grateful that there is something healthy i can have now to calm my nerves and my mind.

In a report published in Pediatric Dermatology in 2018, scientists reported three cases of topical CBD (applied as an oil, cream, and spray) use in children with a rare, blistering skin condition known as epidermolysis bullosa. Applied by their parents, all three people reported faster wound healing, less blisters, and improvement of pain. One person was able to completely wean off oral opioid analgesic pain medication. There were no adverse effects reported.
REM behavior disorder: REM behavior disorder (RBD) is a parasomnia disorder characterized by shouting, becoming physically agitated, or otherwise acting out during sleep. For many, RBD is a symptom of a larger, more serious condition or disorder, such as Alzheimer’s disease or PTSD. CBD oil minimizes the symptoms of RBD, and also alleviates the anxiety and painful symptoms that often accompany disorders that lead to RBD.
Take your medicine. If your diabetes can’t be controlled with diet, exercise, and weight control, your doctor may recommend medicine or insulin. Most people who have type 2 diabetes start with an oral medicine (taken by mouth). Oral medicines can make your body produce more insulin. They also help your body use the insulin it makes more efficiently. Some people need to add insulin to their bodies with insulin injections, insulin pens, or insulin pumps. Always take medicines exactly as your doctor prescribes. Oral medicine doesn’t work for everyone. It is not effective in the treatment of type 1 diabetes. Insulin therapy is necessary for all people who have type 1 diabetes and for some people who have type 2 diabetes. If you need insulin, you’ll have to give yourself a shot (either with a syringe or with an insulin pen). Your doctor will tell you which kind of medicine you should take and why.

What you need to know about chemotherapy Chemotherapy is a widespread and effective way of treating cancerous tissues in the body. Chemotherapy destroys cancer cells, but its side effects can be debilitating and hard to manage. Find out here all about chemotherapy and how it works and whether the positive results balance out with the negatives ones. Read now
Diabetic ketoacidosis can be caused by infections, stress, or trauma, all of which may increase insulin requirements. In addition, missing doses of insulin is also an obvious risk factor for developing diabetic ketoacidosis. Urgent treatment of diabetic ketoacidosis involves the intravenous administration of fluid, electrolytes, and insulin, usually in a hospital intensive care unit. Dehydration can be very severe, and it is not unusual to need to replace 6-7 liters of fluid when a person presents in diabetic ketoacidosis. Antibiotics are given for infections. With treatment, abnormal blood sugar levels, ketone production, acidosis, and dehydration can be reversed rapidly, and patients can recover remarkably well.
The outlook for patients with arthritis depends on its severity, complications, and whether or not there are non-joint manifestations of the disease. For example, rheumatoid arthritis can affect the lungs, kidneys, eyes, etc. Chronic joint inflammation can lead to permanent damage to the joint and loss of joint function, making movement difficult or impossible.
Concern about the dangers of marijuana abuse led to the banning of cannabinoids for medicinal use in the U.S. and many other countries in the 1930s and 1940s. It took decades until they came to be considered again as compounds of therapeutic value, and even now their uses are highly restricted yet more and more states have now legalized medical marijuana.
While very few clinical trials have explored the pain-relieving effects of CBD oil, a report published in the Cochrane Database of Systematic Reviews in 2018 examined the use of a variety of cannabis-based medicines and found they might be of some benefit in the treatment of chronic neuropathic pain. A type of pain triggered by damage to the somatosensory system (i.e., the system responsible for processing sensory stimuli), neuropathic pain often occurs in people with conditions like diabetes and multiple sclerosis.
Gouty arthritis develops as the result of uric acid buildup in the bloodstream. The uric acid forms crystals which cause acute inflammation in a joint. The big toe, ankle, knee, and elbow are the most common joints affected. A gout attack can be acutely painful. The inflamed joint becomes red and very sensitive to touch. Gout attacks are most often treated with medicine rather than surgery. Long term, many patients develop soft tissue masses (tophi) over the affected joints.

for colon cancer, see Engstrom PF, Arnoletti JP, Benson AB, Chen YJ, Choti MA, Cooper HS, Covey A, Dilawari RA, Early DS, Enzinger PC, Fakih MG, Fleshman J, Fuchs C, Grem JL, Kiel K, Knol JA, Leong LA, Lin E, Mulcahy MF, Rao S, Ryan DP, Saltz L, Shibata D, Skibber JM, Sofocleous C, Thomas J, Venook AP, Willett C (September 2009). "NCCN Clinical Practice Guidelines in Oncology: colon cancer". Journal of the National Comprehensive Cancer Network. 7 (8): 778–831. PMID 19755046.
Pharmaceutical companies producing oils are subject to a pharmaceutical production licence for controlled drugs, issued by government regulators. Currently there are no pharmaceutical companies producing cannabis oil as a medicine. This might change in the future when a standardised, GMP-certified production method becomes available, setting the standards for the production of cannabis oil as a pharmaceutical product.
Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose comes from the foods you eat. Insulin is a hormone that helps the glucose get into your cells to give them energy. With type 1 diabetes, your body does not make insulin. With type 2 diabetes, the more common type, your body does not make or use insulin well. Without enough insulin, the glucose stays in your blood. You can also have prediabetes. This means that your blood sugar is higher than normal but not high enough to be called diabetes. Having prediabetes puts you at a higher risk of getting type 2 diabetes.
for other general statements see Smith TJ, Hillner BE (May 2011). "Bending the cost curve in cancer care". The New England Journal of Medicine. 364 (21): 2060–5. doi:10.1056/NEJMsb1013826. PMC 4042405. PMID 21612477. and Peppercorn JM, Smith TJ, Helft PR, Debono DJ, Berry SR, Wollins DS, Hayes DM, Von Roenn JH, Schnipper LE (February 2011). "American society of clinical oncology statement: toward individualized care for patients with advanced cancer". Journal of Clinical Oncology. 29 (6): 755–60. doi:10.1200/JCO.2010.33.1744. PMID 21263086.
Extraction: The method by which CBD oil is processed from hemp plants can be very telling. Some manufacturers extract and process the oil using toxic materials like propane or butane; in most cases, these oils are cheaply priced. Safer extraction and processing agents include ethanol, which cleans the hemp plant of unwanted toxins; and supercritical carbon dioxide extraction, which strips harmful materials from the plant by changing the carbon dioxide’s temperature and pressure settings.
Individuals with arthritis can benefit from both physical and occupational therapy. In arthritis the joints become stiff and the range of movement can be limited. Physical therapy has been shown to significantly improve function, decrease pain, and delay need for surgical intervention in advanced cases.[43] Exercise prescribed by a physical therapist has been shown to be more effective than medications in treating osteoarthritis of the knee. Exercise often focuses on improving muscle strength, endurance and flexibility. In some cases, exercises may be designed to train balance. Occupational therapy can provide assistance with activities. Assistive technology is a tool used to aid a person's disability by reducing their physical barriers by improving the use of their damaged body part, typically after an amputation. Assistive technology devices can be customized to the patient or bought commercially.[44]
Replication of the data contained within the DNA of living cells will probabilistically result in some errors (mutations). Complex error correction and prevention is built into the process and safeguards the cell against cancer. If a significant error occurs, the damaged cell can self-destruct through programmed cell death, termed apoptosis. If the error control processes fail, then the mutations will survive and be passed along to daughter cells.
There are two major types of diabetes, called type 1 and type 2. Type 1 diabetes was also formerly called insulin dependent diabetes mellitus (IDDM), or juvenile-onset diabetes mellitus. In type 1 diabetes, the pancreas undergoes an autoimmune attack by the body itself, and is rendered incapable of making insulin. Abnormal antibodies have been found in the majority of patients with type 1 diabetes. Antibodies are proteins in the blood that are part of the body's immune system. The patient with type 1 diabetes must rely on insulin medication for survival.

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The most common type of arthritis, osteoarthritis involves wear-and-tear damage to your joint's cartilage — the hard, slick coating on the ends of bones. Enough damage can result in bone grinding directly on bone, which causes pain and restricted movement. This wear and tear can occur over many years, or it can be hastened by a joint injury or infection.
CBD oil is derived from cannabis plants that have high levels of cannabidiol (CBD) while having low levels of THC. At PureKana, our CBD oils always have less than 0.2% THC. These extracts can then be used in paste form, or mixed with other oils such as hemp seed oil, to lower the viscosity of the extract. The cannabidiol (CBD) content of CBD oil varies tremendously, since the manufacturers use a varying assortment of cannabis plants and preparation techniques. We produce CBD oil with a high concentration of CBD and containing 0.02% THC.
CBD oil is derived from cannabis plants that have high levels of cannabidiol (CBD) while having low levels of THC. At PureKana, our CBD oils always have less than 0.2% THC. These extracts can then be used in paste form, or mixed with other oils such as hemp seed oil, to lower the viscosity of the extract. The cannabidiol (CBD) content of CBD oil varies tremendously, since the manufacturers use a varying assortment of cannabis plants and preparation techniques. We produce CBD oil with a high concentration of CBD and containing 0.02% THC.
Georgia’s law is much more limited than some other states’ medical marijuana laws. For example, it does not legalize the sale or possession of marijuana in leaf form, and it does not authorize retail stores to sell marijuana or products made from the marijuana plant. It does not authorize physicians to prescribe marijuana for medical use. It is intended solely to protect qualified persons from criminal prosecution for possessing low THC oil for medicinal purposes. 
I am currently going through red skin syndrome/topical steroid withdrawal. The only cure as of now is time(6 months to 3 years) and waiting out horrible eczema-like flares. My main issue is burning/tingling skin that is almost constant. Steroids close off blood vessels and when you stop them they 'wake' up causing this nerve discomfort/pain. I've been smoking medical cannabis for the duration of my recovery(1.5 years) and It's done wonders except that the flare is around my mouth and I'm afraid the smoking is causing more issues.. as well as helping. I need to step up my game and take a different approach. I am wondering how to go about using cbd but I don't know where to start and was wondering if you could help. Thank you
We are all aware of the promising therapeutic benefits that can be derived from using CBD oil, but it also may interact poorly with other prescription and over-the-counter drug and medications. Since side effects are unavoidable when taking CBD extracted from both hemp and marijuana, its interaction with drugs that are taken simultaneously may result in adverse effects or serious complications. Hemp CBD oil can inhibit the liver’s ability in processing certain medications, which may result in an overall increase in processing times. As the liver experiences difficulty in metabolizing, drugs stay longer in the body. In some cases, the interaction could cause serious side effects or even overdose. With this in mind, you should consult your physician before starting on any hemp CBD oil therapy and may be required to alter your CBD dosage.
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That leaves those touting CBD’s effectiveness pointing primarily to research in mice and petri dishes. There, CBD (sometimes combined with small amounts of THC) has shown promise for helping pain, neurological conditions like anxiety and PTSD, and the immune system—and therefore potentially arthritis, diabetes, multiple sclerosis, cancer, and more.
The dosages mentioned do not take into account the strength of the tincture. I have Elixinol 300, I took 1/2 dropper (0.5ml, which offers 5mg of CBD) as indicated on the bottle and felt severely nauseous for 3 hours thereafter. There is no way I cold take this dose twice per day, as recommended on the bottle. The high dosages on this site must surely be for much weaker concentrations?
Hi Colleen, it's almost a year later and I'm wondering how you're doing. I'm experiencing a recurrence of Stage 3 ovarian, originally diagnosed in 2011. I've decided to get some chemo, not sold on another 6 cycles though. As a new MMJ patient, I'm still going to go through with Rick Simpson Oil (THC+CBD,) and I just joined a program with my local dispensary to get CBD capsules for $2 each when I order them at least 30 at a time. I hope you're doing well!! I'm off to do more research on dosing. **NOTE: If you have ANY experience with CBD treatment of ovarian cancer, PLEASE respond. Thank you!!

This tincture is processed using the brand’s signature ‘Gold Formula,’ a full spectrum blend of terpenes, phytocannabinoids, fatty acids, and vitamin E. The drops are offered in three concentrations: 250mg in a 1-oz. container, or 750mg and 1,500mg in 2-oz. containers. Plus CBD Oil recommends taking half a dropper, or 15 drops, per dose. The drops are vegetarian-friendly and free of GMOs, gluten, and glycerin.
I just ordered the CBD isolate now available only by phone I guess for maybe the 3rd or 4th time and have now been using it probably 6 months now. I have multiple health issues including fibromyalgia. Also there are a number of things I am sensitive to and cannot ingest so the pure Isolate is best for me - dont have to worry at all about what else is in the product. I think it is helping me tremendously and I highly recommend trying it. I have reduced pain and less brain fog. I have always got my product quickly with no transaction problems at all. Thank you MedTerra
As of November 2016, 33 states and the District of Columbia legally allow cannabis for personal medical use. Rules surrounding the use of medical cannabis (medical marijuana) vary by state. The first state in the union to legalize the medical use of marijuana was California in 1996. States that allow medical marijuana include: Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Hawaii, Illinois, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nevada, New Hampshire, New Jersey, New Mexico, North Dakota, New York, Ohio, Oregon, Pennsylvania, Rhode Island, Utah, Vermont, Washington, and the District of Columbia. It is important to recognize that these state marijuana laws do not change the fact that using marijuana continues to be an offense under Federal law.

Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, or its action, or both. Diabetes mellitus, commonly referred to as diabetes (as it will be in this article) was first identified as a disease associated with "sweet urine," and excessive muscle loss in the ancient world. Elevated levels of blood glucose (hyperglycemia) lead to spillage of glucose into the urine, hence the term sweet urine.


The key mission of WHO’s work in cancer control is to promote national cancer control policies, plans and programmes that are harmonized with strategies for noncommunicable diseases and other related health concerns. Our core functions are to set norms and standards for cancer control including the development of evidence-based prevention, early diagnosis, screening, treatment and palliative care programmes as well as to promote monitoring and evaluation through registries and research that are tailored to the local disease burden and available resources.

The American Cancer Society, the Centers for Disease Control and Prevention, the National Cancer Institute, and the North American Association of Central Cancer Registries collaborate annually to provide updated information about cancer occurrence and trends in the United States. This year's report highlights the increasing burden of liver cancer and emphasizes the importance of public health efforts to prevent, identify, and treat chronic hepatitis B and C viral infections and to promote reductions in other key risk factors for liver cancer.
The drops are extracted from non-GMO hemp plants grown in the U.S. Only aerial parts of the hemp plants are used, ensuring higher quality and speedier effects. CBDistillery provides third-party testing information for the drops on the product’s website. Customers who order the drops directly from CBDistillery may return the product for a full refund. Free shipping is available for U.S. orders of $75 or more.

Decreased mobility, in combination with the above symptoms, can make it difficult for an individual to remain physically active, contributing to an increased risk of obesity, high cholesterol or vulnerability to heart disease.[24] People with arthritis are also at increased risk of depression, which may be a response to numerous factors, including fear of worsening symptoms.[25]
Because of this classification, it's not easy for researchers to get their hands on the drug. "That's not to say you can't do it, but there are hoops you need to jump through that can be a pain, which may deter researchers from going into this space," Bonn-Miller said. "Relatively speaking, it's a small group of people in the U.S. that do research on cannabinoids in humans."
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